The PGwoundHeal system utilizes a novel peptide hydrogel platform and provides advanced wound healing techniques. PGwoundHeal is biocompatible and bioabsorbable; fast healing and no infection; easy for gel manipulation in terms of strength, mixing, dressing, molding, or bioprinting; xenogenic sourced materials; nontoxic catalysts; easy uploading cells, healing promotors, and drugs as needed. PGwouldHeal system is a powerful tool for open wound treatment caused by traumatic and diabetic cases. PGwoundHeal can be applied to wound surface directly by using various devices, such as hands, syringe, and sprayer.