The PGphArm system provides unique enabling tool for high throughput drug screening (efficacy and toxicity) process. It utilizes PepGel’s platform technology with superior properties and features for various cells culture or co-culture in 3D microenvironment as well as organ cells or organoid in 3D. PGphArm system is designed to mimic the natural extracellular matrix (ECM), a 3D network matrix composed of fibrous matrix proteins that provides structural integrity for cell survival, with a system that can be handled at room conditions. PGphArm system allows mimicking animal drug testing and accurately evaluating cell/organoid resistance to drugs.