The PGbioInk system offers enabling technologies of robust bio-ink design and production that are suitable for a variety of cells performance to meet advanced tissue biofabrication via 3D bioprinting techniques. Bio-ink selection has been severely limited the advancement of bioprinting for human tissue, organs, and regenerative medicine. Each cell type requires a specific microenvironment for living. A biomaterial good for cells may not meet the bio-ink specifications or vice versa. PGbioInk is the home for cells, biocompatible, so-gel reversible by shearing force, easy for uploading cells/nutrients/growth factors/small molecules/drugs at room condition or 37°C.